If you want brighter, firmer, and more radiant skin, WE Clinic introduces you to Mesotherapy a popular treatment that gently improves skin quality and restores a youthful glow.

Many people have heard about facial Mesotherapy but still wonder: What exactly is it? How is it done? Is it safe? And how long will the results last?

In this article, we’ll answer all your questions. From how Mesotherapy works, the improvements you can expect, to simple aftercare tips that help your skin stay fresh and luminous for longer.

What Is Mesotherapy for Skin Brightening?

Before deciding on Mesotherapy, it’s important to understand what this treatment actually is.

Mesotherapy also known as facial brightening injections is a shortcut to glowing skin. The procedure uses very fine needles (about 27–30G, thinner than a sewing pin) to deliver vitamins, collagen, antioxidants, and other nourishing ingredients directly into the middle layer of the skin (known as the mesoderm).

Unlike topical creams, which only work on the skin’s surface, Mesotherapy penetrates deeper, allowing the skin to fully absorb active ingredients for more effective rejuvenation. This makes the treatment a highly efficient way to restore clarity, hydration, and radiance from within.

Types of Mesotherapy for Skin Brightening

There are generally two main methods of Mesotherapy for facial rejuvenation. Each technique comes with its own advantages and limitations, making it important to choose the right approach based on your skin condition and desired results.

Mesotherapy with Microneedle Injections

One common method of facial Mesotherapy involves using very fine needles to create tiny microinjections across the skin’s surface. These shallow injections allow vitamins and nutrients to penetrate the skin and help stimulate collagen production.

The main advantage of this technique is that it causes minimal discomfort, as the needles only lightly prick the skin. However, there are potential drawbacks: if performed in a clinic with poor hygiene, it can increase the risk of infection, redness, or swelling. Additionally, compared to the more targeted “16-point injection technique,” this method tends to deliver less effective results.

Mesotherapy with the 16-Point Injection Technique

Another advanced approach is the 16-point Mesotherapy technique, where injections are administered along the lymphatic drainage pathways. This method allows the vitamins and active ingredients to be absorbed more effectively, resulting in longer-lasting and more visible improvements compared to the microneedle method.

It also helps reduce bruising, lowers the risk of allergic reactions or infections, and provides a more consistent outcome. The only drawbacks are that the cost is slightly higher and the treatment may cause mild discomfort, as the needle penetrates about 5–10 millimeters into the skin. However, since very fine needles are used, the procedure is generally well tolerated and not considered painful.

What Are the Benefits of Mesotherapy?

Mesotherapy works by delivering vitamins, antioxidants, collagen, and other nourishing ingredients directly into the skin, something that topical creams cannot fully achieve. As a result, Mesotherapy provides a wide range of benefits for the face, including:

Brighter and more radiant skin: Mesotherapy solutions often contain vitamins A, B, C, and E, along with transaminase and glutathione, which help reduce dullness, lighten pigmentation, and create a naturally glowing complexion. These ingredients also support anti-aging by slowing the formation of wrinkles and inhibiting melanin production.
Stronger, healthier skin: With collagen and coenzyme complexes as key components, Mesotherapy helps improve skin elasticity, tighten pores, and restore a plump, refreshed look.
Reduction of acne and skin inflammation: The treatment helps control excess oil production, detoxify the skin, and reduce bacterial activity leading to fewer breakouts and calmer skin.
Fading of dark spots and uneven tone: Mesotherapy reduces hyperpigmentation from acne, melasma, or freckles, while improving hydration and controlling excess sebum, leaving the skin smoother and less prone to new wrinkles.

Who Is a Good Candidate for Mesotherapy?

Almost anyone can undergo Mesotherapy, as it is considered a safe treatment and the injected substances are naturally broken down and eliminated by the body. This makes it highly suitable for people whose skin is easily affected by factors such as stress, lack of sleep, frequent sun exposure, cold weather, or long hours in air-conditioned environments. In many cases, these conditions can lead to dullness, acne, or skin irritation, especially for those who tend to overuse skincare products that clog pores and worsen breakouts.

Mesotherapy is also an excellent option for individuals who dislike applying creams or maintaining an extensive skincare routine. It offers a quick and effective way to improve skin quality and restore radiance without the need for multiple topical products.

How Long Does It Take to See Results from Mesotherapy?

After a Mesotherapy session, results typically begin to appear within about 3 days. The skin often looks more hydrated, plumper, and refreshed. The full effect usually develops between 7 to 14 days, when the skin becomes noticeably brighter and healthier.

How Many Mesotherapy Sessions Are Needed?

For consistent results, Mesotherapy is usually recommended as a series of treatments. During the first month, sessions are often performed once a week. After that, maintenance can be done every two weeks.

It is important to note that Mesotherapy is not permanent, as the active ingredients are naturally metabolized and fade within 1–2 months. For the best and most long-lasting results, it is advised to follow a regular treatment plan based on your doctor’s recommendations.

Popular Brands of Mesotherapy

The choice of Mesotherapy brand and formula depends on each individual’s skin condition and should always be determined by a doctor after proper consultation. Currently, there are four widely recognized brands of Mesotherapy available:

Made Collagen: Often referred to as “Made Collagen Mesotherapy,” this formula is well-known for improving a wide range of skin concerns, including acne, rashes, melasma, freckles, wrinkles, and dark spots. It also helps detoxify the skin from pollutants and harmful residues.
Filorga: A premium French brand of Mesotherapy that provides intense skin hydration and restoration. Visible results can be noticed from the very first session, leaving the skin plump, luminous, and revitalized.
Alpha Arbutin: This Mesotherapy type directly targets melasma and pigmentation, helping brighten the overall complexion while gradually fading dark patches.
Tensonez / Depigment: Specifically designed to address pigmentation and melasma, this formula helps improve clarity and delivers a visibly brighter, more radiant skin tone.

How to Prepare Before a Mesotherapy Treatment

If you want to stay safe and avoid poor-quality or counterfeit products, you should follow these important steps before undergoing Mesotherapy:

Choose a clinic that meets medical standards, is officially licensed by the Ministry of Public Health, and make sure the procedure is performed only by a qualified doctor.
Always ask to see the brand of the Mesotherapy solution before injection to confirm its safety. At WE Clinic, only high-quality, FDA-approved products are used, and patients are welcome to verify this information.
Clearly explain your skin concerns to the doctor so the most suitable formula can be selected.
Inform the doctor about any allergies or underlying health conditions.
If you are pregnant or breastfeeding, you should avoid Mesotherapy until it is safe to proceed.

Steps of a Mesotherapy Treatment

Mesotherapy feels only like light pricks on the skin, so there is no need to worry about pain. When performed by an experienced clinic, the procedure is safe and straightforward. The doctor will first prepare your skin and then carry out the injections as follows:

The face is thoroughly cleansed, and an ice pack is applied for about 30–45 minutes to minimize discomfort.
The Mesotherapy solution is then injected into approximately 10–20 points across the face, depending on the individual’s skin condition. The process is quick and far less painful than most people expect.
Once the session is complete, patients can return home immediately with no downtime.

Aftercare Tips Following a Mesotherapy Treatment

After receiving Mesotherapy, you can return to your daily activities as usual without any downtime. However, to maximize results and ensure the treatment lasts longer, it is important to follow these aftercare tips:

Avoid massaging or pressing the treated areas immediately after the procedure.
If redness or bruising occurs at the injection sites, apply a cold compress within the first 48 hours, then switch to warm compresses as advised by your doctor.
Do not apply skincare products directly on the needle marks for the first night.
Avoid smoking and heavy alcohol consumption.
Apply sunscreen regularly to protect the skin.
Get enough sleep and avoid staying up late, as rest is essential for skin recovery.

Possible Side Effects of Mesotherapy

Although Mesotherapy is generally safe, some mild side effects may occur after treatment. These reactions are temporary and usually resolve within a few days:

Redness and swelling may appear at the injection sites but typically subside within 2–3 days once the solution has been fully absorbed into the skin.
Bruising can develop in some cases, often appearing 2–3 days after treatment. Applying Reparil Gel can help speed up recovery.
Skin rashes may occasionally occur, caused by factors such as minor infections, allergic reactions to anesthetic, or irritation from needle marks.

If any unusual or severe symptoms persist, it is important to consult a qualified doctor immediately for proper diagnosis and treatment.

Frequently Asked Questions About Mesotherapy

Does Mesotherapy Hurt?

In most cases, Mesotherapy does not require anesthesia. Instead, a cold compress is applied to numb the skin and reduce discomfort. The injections are placed only 5–10 millimeters deep into the skin, with a small amount of solution and within a short treatment time. As a result, the procedure is usually well tolerated and not considered painful. Some patients may feel a slight warming sensation on the skin, but it is not uncomfortable.

Is Mesotherapy Worth It?

Mesotherapy is considered a safe treatment for enhancing skin brightness, as it leaves no harmful residues in the body. The procedure works by delivering nourishing ingredients directly into the middle layer of the skin, helping restore clarity, smoothness, and firmness. Since the treatment is simple, requires no downtime, and provides faster results compared to many expensive skincare creams on the market, Mesotherapy is seen as a valuable and effective option for anyone looking to improve their skin.

Can You Do Mesotherapy at Home by Yourself?

Mesotherapy is not a procedure that should ever be done at home by yourself. Using unapproved or counterfeit products can cause serious long-term damage. Some illegal formulations may contain steroids or hormones, which over time can make the skin more sensitive to sunlight, trigger melasma, or even increase the risk of skin cancer.

There are also major concerns about hygiene. Performing injections without proper medical standards can easily lead to infections or wounds that do not heal properly.

For safety and effective results, Mesotherapy should only be performed at a certified clinic by a qualified doctor, who can assess your skin condition and choose the right formula for your needs. This ensures both safety and the best possible outcome.

How Long Do the Results of Mesotherapy Last?

The effects of Mesotherapy typically last about 1–2 months. With regular maintenance sessions, the results can be prolonged. To keep your skin looking its best, it is important not only to continue with consistent treatments but also to maintain healthy lifestyle habits. Avoid excessive sun exposure, lack of sleep, stress, smoking, and heavy alcohol consumption, as these factors can damage the skin and shorten the benefits of treatment.

Mesotherapy is an excellent option for skin rejuvenation, helping brighten the complexion, reduce acne and irritation, and calm inflammation more effectively than many expensive creams. However, it is always recommended to consult with a qualified doctor to ensure that Mesotherapy is suitable for your skin type and to determine which brand or formula will provide the safest and most effective results.

For further questions about Mesotherapy or to book a consultation, you can contact our expert doctors at We clinic through facebook or Line for personalized advice.

Mesotherapy for Glowing Skin: What It Is, Benefits, and How Long It Lasts